CMP-5 hydrochloride ( PRMT5-IN-5 )

Catalog No. M10145 CAS No. 1030021-40-9

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Product Name

CMP-5 hydrochloride
Note

Research use only, not for human use.
Brief Description

CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival.
Description

CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells; displays no activity against other type I (PRMT1 and PRMT4) and type II (PRMT7) enzymes; inhibition of PRMT5 leads to lost recruitment of a PRMT5/p65/HDAC3-repressive complex on the miR96 promoter, restored miR96 expression, and PRMT5 downregulation.
Synonyms

PRMT5-IN-5
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

——
Indication

——

CAS Number

1030021-40-9
Formula Weight

351.87
Molecular Formula

C21H22ClN3
Purity

>98% (HPLC)
Solubility

——
SMILES

CCN1C2=C(C3=C1C=CC=C3)C=C(CNCC4=NC=CC=C4)C=C2.[H]Cl
Chemical Name

1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine hydrochloride

1. Alinari L, et al. Blood. 2015 Apr 16;125(16):2530-43.

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